Ludogorets arrived in Milan wearing masks and gloves to protect themselves from coronavirus ahead of their clash with Inter in the Europa League on Thursday.
Italy has become the latest country to suffer an outbreak and various sporting events, including the Six Nations, have been affected.
Twelve people have died from the disease in Italy and the country has reported a total of 374 cases.
And Bulgarian side Ludogorets were taking no chances upon their arrival in Milan.
Ludogorets fitness coach says the outbreak has had a big impact on his team’s preparation for the second leg as they bid to overturn a 2-0 deficit.
“This has transformed our plans because we were supposed to stay in Milan for two nights, arriving the day before and then leaving the day after,” he told Spanish outlet Mundo Deportivo.
“Instead, we are now leaving Milan straight after the match. During our stay, we have been asked to stay in our hotel rooms for as long as possible, to step outside just to eat, and try not to interact with the hotel staff.
“It’s going to be a great game in a wonderful stadium, even if it’s empty.”
Four Serie A fixtures were postponed on the weekend as the killer bug begins to surface in different parts of the country.
Meanwhile, Italy’s trip to Dublin to face Ireland in the Six Nations has been also been postponed.
China, where the virus first emerged, has reported 77,658 cases and 2,663 deaths.