Tottenham manager Jose Mourinho has tinkered with his team again as he reverts to a back-four against Southampton.
He has picked Tanguy Ndombele once again after the Frenchman completed his first full Premier League game against Norwich and youngster Ryan Sessegnon remains in the side.
Many expected changes after an error-strewn match against Norwich in their last game and Mourinho has made two for their trip to the south coast.
Lucas Moura comes into the team for loan star Giovani Lo Celso and Moussa Sissoko returns in place of Juan Foyth.
This should see the Sissoko and Ndombele in central midfield together, giving the latter scope to break forward.
Moura is set to play in the forward line after coming on as a substitute against Norwich on December 28.
Confirmed teams
Southampton: McCarthy, Cedric, Stephens, Bednarek, Bertrand, Armstrong, Ward-Prowse, Hojbjerg, Djenepo, Ings, Redmond.
Substitutes: Yoshida, Vestergaard, Long, Adams, Romeu, Obafemi, Gunn.
Tottenham Hotspur: Gazzaniga, Aurier, Alderweireld, Vertonghen, Sessegnon, Sissoko, Ndombele, Lucas Moura, Alli, Eriksen, Kane.
Substitutes: Sanchez, Winks, Lamela, Vorm, Lo Celso, Skipp, Tanganga.
Referee: Mike Dean (Wirral)
