Paul Pogba, Anthony Martial and Luke Shaw have been ruled out of Manchester United’s trip to West Ham on Sunday.
Ole Gunnar Solskjaer will once again be without the trio, who were absent from the Red Devils’ 1-0 win over Leicester last weekend.
Pogba (ankle), Martial (thigh) and Shaw (hamstring) will be given an extra week to recover.
Meanwhile, Daniel James could feature at the London Stadium after missing his side’s Europa League victory against Astana on Thursday.
When asked if Pogba and Martial would be fit for the weekend, United boss Solskjaer said: “Not really, no.
“They’ve not been training yet so I don’t think so. Luke won’t be ready.
“Daniel James? I don’t know. He’s not trained the last few days. Hopefully, but I’m not sure. We’ll have a recovery day with everyone tomorrow and we’ll see on Saturday.”
In Martial’s continued absence, Marcus Rashford is likely to the lead the line at West Ham.
The England forward, 21, has not scored from open play since the opening day of the season and struggled against Astana.
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However, Solskjaer insists he is not worried about Rashford’s form.
The Norwegian added: “He is still learning what finishes to make in different circumstances. I don’t worry about it.
“One chance against Astana he could have finished with his left instead of his right but we are working with him every single day in training because he wants to improve.
“There are not many traditional number nines left now. Marcus can play right, left, up front on his own, or as a number 10.
“But the big thing is he is still young. As a striker he won’t hit his peak until he is 26 or 27.”