Southampton welcome back Nathan Redmond to their starting line-up as they entertain Bournemouth on Friday night.
The winger returns to action after sustaining an ankle injury during a Carabao Cup tie at Fulham last month, replacing injured Moussa Djenepo.
As for Bournemouth, Jefferson Lerma starts in place of Lewis Cook while Ryan Fraser, who scored in their win over Everton last weekend, is on the bench.
The south coast derby is the first clash of gameweek six of the 2019/20 Premier League season and both sides will know they will break into the top four with a win.
Saints managed to survive relegation last season after appointing Ralph Hasenhuttl as manager in December and they look a more assured outfit this season.
However, they’ve yet to taste victory at home so far this campaign, with their two wins this season coming at Brighton and Sheffield United.
Southampton boss Hasenhuttl said: “I expect a tough game from two teams who want to win.
“We have to be very flexible against this opponent, it could be we have to change the shape a few times, but we know we have players on the pitch who can do this.”
Meanwhile, Bournemouth are level on seven points with Saints and have two victories as well – Aston Villa (A) and Everton (H)
But they’ve never won at Southampton in the Premier League and Cherries boss Eddie Howe believes it’s time that duck was broken.
He said: “We have had some really good battles in the Premier League against Southampton, some successes, some disappointments, but that all adds to make the game what it is.
“We haven’t won a game yet at Southampton in the Premier League and we are desperate to do that as soon as we can.
“We are aware this game holds extra importance for our supporters, and everybody locally, so that has its own responsibility.”
Southampton: Gunn, Cedric, Vestergaard, Bednarek, Danso, Romeu, Hojbjerg, Ward-Prowse, Boufal, Redmond, Adams
Subs: McCarthy, Yoshida, Stephens, Bertrand, Armstrong, Ings, Long
Bournemouth: Ramsdale, Stacey, Cook, Ake, Rico, H.Wilson, Billing, Lerma, King, Solanke, C. Wilson
Subs: Boruc, Surman, Mepham, Simpson, L.Cook, Fraser, Ibe
LIVE on talkSPORT
Check out all the live commentaries coming up across the talkSPORT network this weekend
- Leicester vs Tottenham (Saturday, 12:30pm) – talkSPORT
- Leeds vs Derby (Saturday, 12:30pm) – talkSPORT 2
- Everton vs Sheffield United (Saturday, 3pm) – talkSPORT 2
- Newcastle vs Brighton (Saturday, 5:30pm) – talkSPORT
- West Brom vs Huddersfield (Sunday, 12pm) – talkSPORT 2
Saturday is GameDay on talkSPORT. We’ll bring you LIVE commentary of Premier League games across all three time slots on Saturday – 12.30pm, 3pm and 5.30pm – with Leicester vs Tottenham among our games this weekend.